Variations of reported outcomes in randomised controlled trials on interventions for the treatment of pelvic organ prolapse
Stergios Doumouchtsis, James Duffy
Stergios Doumouchtsis, James Duffy. Variations of reported outcomes in randomised controlled trials on interventions for the treatment of pelvic organ prolapse.
PROSPERO 2017 CRD42017062456 Available from:
The aim is to review the outcomes and outcome measures reported in randomized controlled trials and their relationship with methodological quality, year of publication, commercial funding, and journal impact factor.
Sources searched include Cochrane Central Register of Controlled Trials (CENTRAL), Embase and MEDLINE from inception to April 2017.
Types of study to be included
Randomised controlled trials.
Condition or domain being studied
Pelvic organ prolapse.
Treatments for pelvic organ prolapse.
Review of reported outcomes, change of severity of prolapse symptoms, quality of life parameters etc.
Relationship of outcomes and outcome measures with methodological quality, year of publication, commercial funding, and journal impact factor.
Data extraction (selection and coding)
Risk of bias (quality) assessment
For methodological quality: Jadad score; range, 1-5.
Strategy for data synthesis
We will use univariate and bivariate analyses with Spearman Rho and Mann-Whitney U tests.
Analysis of subgroups or subsets
We will use a multivariate linear regression model to assess relationship associations between outcome reporting quality and other variables.
Contact details for further information
Organisational affiliation of the review
Epsom General Hospital Department of Obstetrics and Gynaecology Dorking Rd, Epsom KT18 7EG
Review team members and their organisational affiliations
Professor Stergios Doumouchtsis.
Dr James Duffy.
Anticipated or actual start date
28 April 2017
Anticipated completion date
26 January 2018
Conflicts of interest
The lead reviewer (SD) has given talks on this topic at workshops, seminars, and conferences. The lead reviewer has received honoraria for talks (Astellas) and sponsorship for registration accommodation and travel fees for the attendance of conferences (European Speciality Pharma).
Stage of review
Subject index terms status
Subject indexing assigned by CRD
Subject index terms
Female; Humans; Pelvic Organ Prolapse; Uterine Prolapse
Date of registration in PROSPERO
10 April 2017
Date of publication of this version
10 April 2017
Details of any existing review of the same topic by the same authors
Stage of review at time of this submission
Stage / Started / Completed
Preliminary searches / Yes / No
Piloting of the study selection process / No / No
Formal screening of search results against eligibility criteria / No / No
Data extraction / No / No
Risk of bias (quality) assessment / No / No
Data analysis / No / No